TREATMENT FOR MESOTHELIOMA

10 Apr

Malignant mesothelioma can be treated though the following procedures bellow:

SURGERY – Surgery by itself has proved disappointing in one large series, the median survival with surgery including extrapleural pneumonictomy was only 11. 7 months . However research indicates varried success when used in combination with radiation and chemotherapy.

RADIATION – For individuals who have localized disease, and who can tolerate a radical surgery, radiation is often given. post-operatively as a consolidative treatment. The entire hemi-thorax is treated with radiation    theraphy, often given simultaneously with chemotherapy. Delivering radiation and chemotherapy after a radical surgery has led to extended life expectancy in selected patient populations with some patients surviving more than 5 years.

CHEMOTHERAPY – Chemotherapy is the only treatment for mesothelioma that has been proven to improve survival in randomized and controlled trials . This trial was the first to report a survival advantage from chemotherapy in malignant pleural mesothelioma, showing a statistically significant improvement in median survival from 10 months in the patients treated with cisplatin alone to 13.3 months in the group of patients treated with cisplatin in the combination with premetrexed and who also received supplementation with folate and vitamins B12.

IMMUNOTHERAPY – Treatments regimens involving immunotherapy have yielded variable results. Indeed this trial was suspended in view of the unacceptably high levels of it of IL-12 toxicity and and the severity of side effects such as fever and cachexia.

HEATED INTRAOPERATIVE INTRAPERITONEAL CHEMOTHERAPY 
     -A procedure known as heated intraoperative intraperitoneal chemotherapy was developed by Paul Sugarbaker at the Washington Cancer Institute. The surgeon removes as much of the tumor as possible followed by the direct administration of chemotherapy agent, heated to between 40 and 48C

MULTIMODALITY THERAPY – All of the standard approaches to treating solid tumors — radiation, chemotherapy and surgery , have been investigated in patients with malignant pleural mesothelioma.

ALTERNATIVE MEDICINE – The medical plant Ashwagandha or also know as Withania somnifera has long been used in Indian Ayurvidic Medicine. It has been tested in vitro and vivo as a treatment for malignant pleural mesothelioma.

References:

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